ReferenceID 4397
Vanillin augments liver regeneration effectively in Thioacetamide induced liver fibrosis rat model
Life Sci
AIMS: This study has been designed to investigate the role of vanillin either as prophylaxis or treatment in liver regeneration augmentation and liver fibrosis regression in thioacetamide (TAA) induced liver damage. MATE
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Record Fields
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- Reference Id
- 4397
- Evidence Id
- 20987
- Core Evidence Id
- 20987
- Source Reference Id
- 2081
- Herb2 Reference Id
- HBREF002878
- Subject Paper Key
- HBIN010473_34637793
- Pubmed Id
- 34637793
- Doi
- 10.1016/j.lfs.2021.120036
- Paper Title
- Vanillin augments liver regeneration effectively in Thioacetamide induced liver fibrosis rat model
- Paper Abstract
- AIMS: This study has been designed to investigate the role of vanillin either as prophylaxis or treatment in liver regeneration augmentation and liver fibrosis regression in thioacetamide (TAA) induced liver damage. MATERIALS AND METHODS: Animals were injected with TAA to induce liver injury (200mg/kg twice weekly) for 8 weeks. In vanillin prophylaxis group; rats were administered vanillin (100 mg/Kg; IP, daily) from day 1 of TAA injection for 8 weeks. In vanillin treatment group; rats were confronted with the same dose of TAA injection for 8 weeks then treated with vanillin (100 mg/Kg, IP, daily) for 4 weeks. ALT, AST activities, serum albumin, hepatic GSH, MDA, HGF, VEGF, IL-6 and TNF-alpha levels were measured and also, MMP-2, TIMP-1 and cyclin D gene expression were determined. Liver sections were stained with H&E and Sirius red and immunostained for Ki-67 and alpha-SMA for histological and immunohistological changes analysis. KEY FINDINGS: Vanillin improved liver function and histology. Also, showed a remarkable increase in hepatic HGF and VEGF level, and up-regulation of cyclin D1 expression accompanied by a significant up-regulation of MMP-2 and down- regulation of TIMP-1. All these effects were accompanied by TNF-alpha, IL-6 and oxidative stress significant attenuation. SIGNIFICANCE: In conclusion, vanillin enhanced liver regeneration in TAA induced liver damage model; targeting growth factors (HGF, VEGF) and cellular proliferation marker cyclin D1. As well as stimulating fibrosis regression by inhibition of ECM accumulation and enhancing its degradation.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Fibrosis; Liver Fibrosis
- Paper Title Cn
- Paper Title En
- Vanillin augments liver regeneration effectively in Thioacetamide induced liver fibrosis rat model
- Bilingual Status
- semi_complete