ReferenceID 4396
Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays
Inflammopharmacology
Terpinen 4-ol, a phytochemical is a monoterpene which has been reported for its anti-inflammatory effect. Present research was planned to check its effect against arthritis through in vitro and in vivo models. Terpinen 4
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Record Fields
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- Reference Id
- 4396
- Evidence Id
- 20986
- Core Evidence Id
- 20986
- Source Reference Id
- 2085
- Herb2 Reference Id
- HBREF002882
- Subject Paper Key
- HBIN010920_35320496
- Pubmed Id
- 35320496
- Doi
- 10.1007/s10787-022-00960-w
- Paper Title
- Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays
- Paper Abstract
- Terpinen 4-ol, a phytochemical is a monoterpene which has been reported for its anti-inflammatory effect. Present research was planned to check its effect against arthritis through in vitro and in vivo models. Terpinen 4-ol was evaluated through in-vitro procedures including blocking of protein (BSA and egg albumin) denaturation and human RBC membrane stabilization. In in vivo study, terpinen 4-ol (15, 30 and 60 mg/kg) was evaluated using formaldehyde and CFA arthritic models. Terpinen 4-ol significantly inhibited increase in paw and joint swelling as compared to diseased group. Terpinen 4-ol showed remarkable antioxidant effect (SOD, reducing power) and also improved body weight, haematological, histopathological and radiological parameters in CFA model. Also, moreover, the excess production of IL-1β, TNF-α, IRAK, and NF-kB were noticeably attenuated in all terpinen 4-ol treated rats, however, IL-17 and IL-10 were distinctly increased compared to arthritic control rats in RT-PCR. Also, terpinen 4-ol showed promising antioxidant effect in DPPH assay. Henceforth, it might be concluded that terpinen 4-ol has anti-arthritic effect which can be attributed to the downregulation of pro-inflammatory cytokines.
- Journal
- Inflammopharmacology
- Publish Year
- 2022
- Experiment Subject
- rat; human
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Arthritis
- Paper Title Cn
- Paper Title En
- Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays
- Bilingual Status
- semi_complete