ReferenceID 4386
Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity
Antioxidants (Basel)
Hydroxytyrosol (HT), the major phenolic compound in olive oil, is attracting increasing interest for its beneficial properties including a notable antioxidant and anti-inflammatory power. In this study, using a combinati
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Record Fields
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- Reference Id
- 4386
- Evidence Id
- 20976
- Core Evidence Id
- 20976
- Source Reference Id
- 2046
- Herb2 Reference Id
- HBREF002843
- Subject Paper Key
- HBIN007410_34356360
- Pubmed Id
- 34356360
- Doi
- 10.3390/antiox10071127
- Paper Title
- Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity
- Paper Abstract
- Hydroxytyrosol (HT), the major phenolic compound in olive oil, is attracting increasing interest for its beneficial properties including a notable antioxidant and anti-inflammatory power. In this study, using a combination of biophysical and cell biology techniques, we have tested the role of HT in the formation of advanced glycation end-products (AGEs). AGEs have a key role in clinical sciences as they have been associated to diabetes, neurodegenerative and cardiovascular diseases. In addition, as the incidence of Alzheimer's disease (AD) is strongly increased in diabetic patients, AGE formation is supposed to be involved in the development of the pathological hallmarks of AD. Our data show that HT selectively inhibits protein glycation reaction in human insulin, and it is able to counteract the AGE-induced cytotoxicity in human neurotypical cells by acting on SIRT1 level and oxidative stress, as well as on inflammatory response. This study identifies new beneficial properties for HT and suggests it might be a promising molecule in protecting against the AGE-induced toxicity, a key mechanism underlying the development and progression of neurodegenerative disorders.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2021
- Experiment Subject
- human; patient
- Experiment Type
- Cell Experiment
- Phenotype Related
- Alzheimer's Disease; Diabetic; Neurodegenerative Disorders; Diabetes; Neurodegenerative And Cardiovascular Diseases
- Paper Title Cn
- Paper Title En
- Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity
- Bilingual Status
- semi_complete