ReferenceID 4367
Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo
J Nutr Biochem
Endometriosis is a benign gynecological condition prevalent among reproductive-aged women. Although active research and studies have been carried out to discover new drugs, surgery and hormone therapy are still the gold
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Record Fields
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- Reference Id
- 4367
- Evidence Id
- 20957
- Core Evidence Id
- 20957
- Source Reference Id
- 1995
- Herb2 Reference Id
- HBREF002792
- Subject Paper Key
- HBIN007081_31952013
- Pubmed Id
- 31952013
- Doi
- 10.1016/j.jnutbio.2019.108328
- Paper Title
- Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo
- Paper Abstract
- Endometriosis is a benign gynecological condition prevalent among reproductive-aged women. Although active research and studies have been carried out to discover new drugs, surgery and hormone therapy are still the gold standard for endometriosis treatment. Nowadays, various flavonoids are considered long-term supplements for different diseases. Myricetin, a flavonol, has antiproliferative, anti- or pro-oxidant, and anticancer effects in gynecological diseases. Here, we reveal for the first time, to our knowledge, the antigrowth effects of myricetin in endometriosis. Myricetin inhibited cell proliferation and cell cycle progression of human VK2/E6E7 and End1/E6E7 cells and induced apoptosis, with the loss of mitochondrial membrane potential and accumulation of reactive oxygen species and calcium ions. Additionally, myricetin decreased the activation of AKT and ERK1/2 proteins, whereas it induced p38 activation in both cell lines. Moreover, myricetin decreased lesion size in the endometriosis mouse model via Ccne1 inhibition. Thus, myricetin has antiproliferative effects on endometriosis through cell cycle regulation.
- Journal
- J Nutr Biochem
- Publish Year
- 2020
- Experiment Subject
- mouse; human; cell lines; human vk2/e6e7 and end1/e6e7 cells; women
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Endometriosis; Benign Gynecological Condition; Gynecological Diseases
- Paper Title Cn
- Paper Title En
- Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo
- Bilingual Status
- semi_complete