ReferenceID 4334
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Nature
Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although the mechanisms by which these changes occur are largely unknown. Here we report that the stress hormone corticosterone-which is
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4334
- Evidence Id
- 20924
- Core Evidence Id
- 20924
- Source Reference Id
- 1947
- Herb2 Reference Id
- HBREF002744
- Subject Paper Key
- HBIN001977_33790465
- Pubmed Id
- 33790465
- Doi
- 10.1038/s41586-021-03417-2
- Paper Title
- Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
- Paper Abstract
- Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although the mechanisms by which these changes occur are largely unknown. Here we report that the stress hormone corticosterone-which is derived from the adrenal gland and is the rodent equivalent of cortisol in humans-regulates hair follicle stem cell (HFSC) quiescence and hair growth in mice. In the absence of systemic corticosterone, HFSCs enter substantially more rounds of the regeneration cycle throughout life. Conversely, under chronic stress, increased levels of corticosterone prolong HFSC quiescence and maintain hair follicles in an extended resting phase. Mechanistically, corticosterone acts on the dermal papillae to suppress the expression of Gas6, a gene that encodes the secreted factor growth arrest specific 6. Restoring Gas6 expression overcomes the stress-induced inhibition of HFSC activation and hair growth. Our work identifies corticosterone as a systemic inhibitor of HFSC activity through its effect on the niche, and demonstrates that the removal of such inhibition drives HFSCs into frequent regeneration cycles, with no observable defects in the long-term.
- Journal
- Nature
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
- Bilingual Status
- semi_complete