ReferenceID 4316
Oleanolic Acid-Enriched Olive Oil Alleviates the Interleukin-6 Overproduction Induced by Postprandial Triglyceride-Rich Lipoproteins in THP-1 Macrophages
Nutrients
Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as a component of functional foods for the prevention of metabolic syndrome, due to its anti-inflammatory activity. We analyzed
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Record Fields
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- Reference Id
- 4316
- Evidence Id
- 20906
- Core Evidence Id
- 20906
- Source Reference Id
- 1895
- Herb2 Reference Id
- HBREF002692
- Subject Paper Key
- HERB006677_34684472
- Pubmed Id
- 34684472
- Doi
- 10.3390/nu13103471
- Paper Title
- Oleanolic Acid-Enriched Olive Oil Alleviates the Interleukin-6 Overproduction Induced by Postprandial Triglyceride-Rich Lipoproteins in THP-1 Macrophages
- Paper Abstract
- Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as a component of functional foods for the prevention of metabolic syndrome, due to its anti-inflammatory activity. We analyzed the effects of OA on inflammatory parameters and signaling proteins in LPS-stimulated THP-1 macrophages. Thus, THP-1 macrophages were incubated with LPS for 48 h after pretreatment with OA at different concentrations. Pretreatment with OA was significantly effective in attenuating IL-6 and TNF-alpha overproduction induced by LPS in macrophages, and also improved the levels of AMPK-alpha. We also evaluated the effects of human triglyceride-rich lipoproteins (TRLs) derived from individuals consuming an OA-enriched functional olive oil. For this purpose, TRLs were isolated from healthy adolescents before, 2 and 5 h postprandially after the intake of a meal containing the functional olive oil or common olive oil, and were incubated with THP-1 macrophages. THP-1 macrophages incubated with TRLs isolated at 2 h after the consumption of the OA-enriched olive oil showed significant lower levels of IL-6 compared to the TRLs derived from olive oil. Our results suggest that OA might have potential to be used as a lipid-based formulation in functional olive oils to prevent inflammatory processes underlying metabolic syndrome in adolescents.
- Journal
- Nutrients
- Publish Year
- 2021
- Experiment Subject
- human; adolescent; lps-stimulated thp-1 macrophages; thp-1 macrophages
- Experiment Type
- Animal Experiment
- Phenotype Related
- Metabolic Syndrome
- Paper Title Cn
- Paper Title En
- Oleanolic Acid-Enriched Olive Oil Alleviates the Interleukin-6 Overproduction Induced by Postprandial Triglyceride-Rich Lipoproteins in THP-1 Macrophages
- Bilingual Status
- semi_complete