ReferenceID 4263
Antidiabetic activities of glycoprotein from pea ( Pisum sativum L.) in STZ-induced diabetic mice
Food Funct
Polysaccharides have hypoglycemic activity and pea protein has high nutritional value. The purified pea glycoprotein PGP2 has been shown to inhibit the activity of alpha-glucosidase and alpha-amylase in previous studies.
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Record Fields
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- Reference Id
- 4263
- Evidence Id
- 20853
- Core Evidence Id
- 20853
- Source Reference Id
- 1794
- Herb2 Reference Id
- HBREF002591
- Subject Paper Key
- HERB005614_33960991
- Pubmed Id
- 33960991
- Doi
- 10.1039/d1fo00535a
- Paper Title
- Antidiabetic activities of glycoprotein from pea ( Pisum sativum L.) in STZ-induced diabetic mice
- Paper Abstract
- Polysaccharides have hypoglycemic activity and pea protein has high nutritional value. The purified pea glycoprotein PGP2 has been shown to inhibit the activity of alpha-glucosidase and alpha-amylase in previous studies. To study the mechanism of PGP2-induced blood glucose lowering in vivo, this paper established a diabetic mouse model by intraperitoneal injection of STZ and high-fat diet, and evaluated the blood-glucose-lowering activity of the pea component PGP2 at different doses. The results showed that intragastric administration of PGP2 could effectively reduce diabetic weight loss and polyphagia symptoms, reduce fasting blood glucose levels in mice, and improve oral glucose tolerance levels in mice. PGP2 could promote insulin secretion and had a protective effect on mouse organs. After intragastric administration of PGP2 in mice, the serum levels of total cholesterol, triglycerides and low-density lipoprotein decreased. PGP2 up-regulated the gene expression of insulin receptor substrates IRS-1 and IRS-2 in liver tissues, thereby reducing insulin resistance. Based on the above experimental results, PGP2 had good hypoglycemic activity and was expected to be developed as a natural medicine for the treatment of type II diabetes.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Diabetic; Polyphagia; Type Ii Diabetes; Diabetic Weight Loss
- Paper Title Cn
- Paper Title En
- Antidiabetic activities of glycoprotein from pea ( Pisum sativum L.) in STZ-induced diabetic mice
- Bilingual Status
- semi_complete