ReferenceID 4260
Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa)
Phytother Res
Cervical cancer is the fourth leading cause of cancer mortality in women worldwide. Beetroot (Beta vulgaris L.) has bioactive compounds that can inhibit the progression of different types of cancer. To analyze the antipr
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Record Fields
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- Reference Id
- 4260
- Evidence Id
- 20850
- Core Evidence Id
- 20850
- Source Reference Id
- 1787
- Herb2 Reference Id
- HBREF002584
- Subject Paper Key
- HERB005429_34494317
- Pubmed Id
- 34494317
- Doi
- 10.1002/ptr.7255
- Paper Title
- Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa)
- Paper Abstract
- Cervical cancer is the fourth leading cause of cancer mortality in women worldwide. Beetroot (Beta vulgaris L.) has bioactive compounds that can inhibit the progression of different types of cancer. To analyze the antiproliferative effects of beet leaf and root extracts, we performed MTT, clonogenic survival, cell cycle analysis, Annexin/PI labeling, and western blotting. Here, we report that 10 and 100 mug/ml of root and leaf extracts decreased cell viability and potentiated rapamycin and cisplatin effects while decreased the number of large colonies, especially at 10 mug/ml (293.6 of control vs. 200.0 of leaf extract, p = .0059; 138.6 of root extract, p = .0002). After 48 hr, 100 mug/ml of both extracts led to increased sub-G1 and G0/G1 populations. In accordance, 100 mug/ml of root extract induced early apoptosis (mean = 0.64 control vs. 1.56 root; p = .048) and decreased cell size (p < .0001). Both extracts decreased phosphorylation and expression of mechanistic Target of Rapamycin (mTOR) signaling, especially by inhibiting ribosomal protein S6 (S6) phosphorylation, increasing cleaved poly(ADP-ribose) polysomerase 1 (PARP1) and Bcl-2-like protein 11 (BIM), and decreasing cyclin D1 expression, which regulates cell cycle progression. Here, we demonstrate that beetroot and leaf extracts could be an efficient strategy against cervical cancer.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- women
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cancer; Cervical Cancer
- Paper Title Cn
- Paper Title En
- Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa)
- Bilingual Status
- semi_complete