ReferenceID 4248
Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
Diabetol Metab Syndr
Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce. Objective: To evaluate the effects of CN ingestion in obese rats. Design: Thirty animals (ob
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Record Fields
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- Reference Id
- 4248
- Evidence Id
- 20838
- Core Evidence Id
- 20838
- Source Reference Id
- 1760
- Herb2 Reference Id
- HBREF002557
- Subject Paper Key
- HERB005067_35676689
- Pubmed Id
- 35676689
- Doi
- 10.1186/s13098-022-00847-4
- Paper Title
- Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
- Paper Abstract
- Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce. Objective: To evaluate the effects of CN ingestion in obese rats. Design: Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose-called 2CN. Treatment was maintained for 28 days. Results: The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate. Conclusions: Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.
- Journal
- Diabetol Metab Syndr
- Publish Year
- 2022
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Non-obese; Liver Damage; Obese
- Paper Title Cn
- Paper Title En
- Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
- Bilingual Status
- semi_complete