ReferenceID 4240
Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage
J Ethnopharmacol
Ethnopharmacological significance and aim: Hura crepitans is commonly used to treat liver diseases in Nigeria and Ghana. Previous studies have supported its ethnomedicinal use in protecting the liver. The present study a
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- Reference Id
- 4240
- Evidence Id
- 20830
- Core Evidence Id
- 20830
- Source Reference Id
- 1738
- Herb2 Reference Id
- HBREF002535
- Subject Paper Key
- HERB004848_34688802
- Pubmed Id
- 34688802
- Doi
- 10.1016/j.jep.2021.114768
- Paper Title
- Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage
- Paper Abstract
- Ethnopharmacological significance and aim: Hura crepitans is commonly used to treat liver diseases in Nigeria and Ghana. Previous studies have supported its ethnomedicinal use in protecting the liver. The present study aimed at assessing the effect of H. crepitans stem bark on the subacute carbon tetrachloride (CCl 4 )-induced liver damage in rats. Materials and methods: The protective activities of ethanolic extract of H. crepitans stem bark was evaluated in CCl 4 -induced subacute liver damage in rats (1:1 v/v in olive oil, intraperitoneally (i.p.), twice weekly for 8 weeks). Blood samples were obtained from the rats and used for some biochemical analysis such as liver function test (Aspartate transaminase, AST; Alanine aminotransferase, ALT; and Alkaline phosphatase, ALP), liver fibrotic indices (Aspartate platelet ratio index, APRI; AST/ALT and AST/PLT ratios) and oxidative stress markers (Malondialdehyde, MDA; Reduced glutathione, GSH; Glutathione S-transferase, GST; Glutathione peroxidase, GPx; and superoxide dismutase, SOD). Histopathological analyses were carried out to determine the expression of pro-inflammatory (NF-κB, COX-2, IL-17 and IL-23) using immunohistochemical techniques. Results: Oral administration of H. crepitans to CCl 4 -induced hepatic injured rats significantly decreased oxidative stress, increased the levels of SOD, GSH, GST and GPx with reduced MDA levels. The plant also mitigated liver injury as evidenced in the significantly reduced levels of AST, ALT and ALP, while it inhibited the inflammatory process via the inhibition of NF-κB, and consequently down-regulateed the pro-inflammatory cytokines COX-2, IL-17 and IL-23, respectively. Biochemical observations were supported by improvement in liver microarchitecture. Conclusion: The Hura crepitans demonstrated antioxidant, antiinflammatory and antifibrotic effect in hepatic injured rats. The study in a way justifies the traditional use of the plant for the treatment of subacute liver diseases in Nigerian Traditional medicine.
- Journal
- J Ethnopharmacol
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Subacute Liver Diseases; Hura Crepitans; Liver Diseases
- Paper Title Cn
- Paper Title En
- Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage
- Bilingual Status
- semi_complete