ReferenceID 4225
Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation
Int J Mol Sci
Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activat
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Record Fields
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- Reference Id
- 4225
- Evidence Id
- 20815
- Core Evidence Id
- 20815
- Source Reference Id
- 1709
- Herb2 Reference Id
- HBREF002506
- Subject Paper Key
- HERB004752_35628567
- Pubmed Id
- 35628567
- Doi
- 10.3390/ijms23105757
- Paper Title
- Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation
- Paper Abstract
- Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examined whether ethanol extracts of Saururus chinensis (Lour.) Baill. (SE) could affect RAGE signaling and vascular relaxation in streptozotocin (STZ)-induced diabetic rats. Treatment with SE inhibited AGEs-modified bovine serum albumin (AGEs-BSA)-elicited activation of NF-κB and could compete with AGEs-BSA binding to RAGE in a dose-dependent manner. Tumor necrosis factor-α (TNF-α) secretion induced by lipopolysaccharide (LPS)-a RAGE ligand-was also reduced by SE treatment in wild-type Ager+/+ mice as well as in cultured peritoneal macrophages from Ager +/+ mice but not in Ager -/- mice. SE administration significantly ameliorated diabetes-related dysregulation of acetylcholine-mediated vascular relaxation in STZ-induced diabetic rats. These results suggest that SE would inhibit RAGE signaling and would be useful for the improvement of vascular endothelial dysfunction in diabetes.
- Journal
- Int J Mol Sci
- Publish Year
- 2022
- Experiment Subject
- mouse; rat; bovine
- Experiment Type
- Animal Experiment
- Phenotype Related
- Vascular Endothelial Dysfunction; Vascular Complications; Diabetic; Diabetes
- Paper Title Cn
- Paper Title En
- Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation
- Bilingual Status
- semi_complete