ReferenceID 4204
Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway
J Ethnopharmacol
Ethnopharmacological relevance: Cyclocarya paliurus (CP) is a traditional Chinese herb and possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia, antioxidant and anti-inflammation
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Record Fields
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- Reference Id
- 4204
- Evidence Id
- 20794
- Core Evidence Id
- 20794
- Source Reference Id
- 1674
- Herb2 Reference Id
- HBREF002471
- Subject Paper Key
- HERB004535_34688801
- Pubmed Id
- 34688801
- Doi
- 10.1016/j.jep.2021.114772
- Paper Title
- Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway
- Paper Abstract
- Ethnopharmacological relevance: Cyclocarya paliurus (CP) is a traditional Chinese herb and possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia, antioxidant and anti-inflammation. Arjunolic acid (AA) is an abundant and bioactive ingredient in CP that shows significant protection against many metabolic diseases such as diabetic complication. Diabetic retinopathy (DR) is a serious complication of diabetes and may lead to vision loss. However, the protective effects and underlying mechanisms of AA against DR is not still understood. Aim of the study: We aimed to investigate whether AA activates AMPK/mTOR/HO-1 regulated autophagy pathway to alleviate DR. Materials and methods: In the study, the STZ-induced diabetic model of rats was established, and AA with 10 and 30 mg/kg dosages was given orally for ten weeks to investigate their effect on retinal injury of DR. H 2 O 2 -induced ARPE-19 cells were applied to evaluate anti-apoptosis and anti-oxidant effect of AA. Results: The results revealed that AA could prevent STZ-induced weight loss and increase the retinal thickness and nuclei counts. The level of HO-1 protein was upregulated both in vivo and in vitro. In addition, AA prevented retinal damage and cell apoptosis through the AMPK-mTOR-regulated autophagy pathway. Furthermore, anti-apoptosis capacity, as well as the expression of HO-1 and LC3 protein, were effectively locked by AMPK inhibitor dorsomorphin dihydrochloride (compound C). Conclusions: This finding implies that AA may be a promising candidate drug by protecting retinal cells from STZ-induced oxidative stress and inflammation through the AMPK/mTOR/HO-1 regulated autophagy pathway.
- Journal
- J Ethnopharmacol
- Publish Year
- 2021
- Experiment Subject
- rat; arpe-19 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Anti-hyperglycemia; Vision Loss; Metabolic Diseases; Anti-hyperlipidemia; Diabetic Retinopathy; Diabetic Complication; Diabetes
- Paper Title Cn
- Paper Title En
- Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway
- Bilingual Status
- semi_complete