ReferenceID 4192
Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells
Neural Regen Res
Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions, such as antioxidation, neuroprotection, and immune modulation. One of the main mechanis
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- Reference Id
- 4192
- Evidence Id
- 20782
- Core Evidence Id
- 20782
- Source Reference Id
- 1655
- Herb2 Reference Id
- HBREF002452
- Subject Paper Key
- HERB004184_34100457
- Pubmed Id
- 34100457
- Doi
- 10.4103/1673-5374.314325
- Paper Title
- Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells
- Paper Abstract
- Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions, such as antioxidation, neuroprotection, and immune modulation. One of the main mechanisms of Alzheimer's disease is that microglia activated by amyloid beta (Aβ) transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding environment. In the present study, immortalized microglial cells were pretreated with L. barbarum extract for 1 hour and then treated with oligomeric Aβ for 23 hours. The results showed that LB extract significantly increased the survival of oligomeric Aβ-induced microglial cells, downregulated the expression of M1 pro-inflammatory markers (inducible nitric oxide synthase, tumor necrosis factor α, interleukin-6, and interleukin-1β), and upregulated the expression of M2 anti-inflammatory markers (arginase-1, chitinase-like protein 3, and interleukin-4). LB extract also inhibited the oligomeric Aβ-induced secretion of tumor necrosis factor α, interleukin-6, and interleukin-1β in microglial cells. The results of in vitro cytological experiments suggest that, in microglial cells, LB extract can inhibit oligomeric Aβ-induced M1 polarization and concomitant inflammatory reactions, and promote M2 polarization.
- Journal
- Neural Regen Res
- Publish Year
- 2021
- Experiment Subject
- immortalized microglial cells; oligomeric aβ-induced microglial cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Tumor; Alzheimer's Disease
- Paper Title Cn
- Paper Title En
- Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells
- Bilingual Status
- semi_complete