ReferenceID 4168
Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice
Pharmacol Res
Our goal was to establish the requirement of beta3 adrenoceptor (beta3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and beta3Adr knockout (KO) male m
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Record Fields
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- Reference Id
- 4168
- Evidence Id
- 20758
- Core Evidence Id
- 20758
- Source Reference Id
- 1605
- Herb2 Reference Id
- HBREF002402
- Subject Paper Key
- HERB003617_32480000
- Pubmed Id
- 32480000
- Doi
- 10.1016/j.phrs.2020.104956
- Paper Title
- Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice
- Paper Abstract
- Our goal was to establish the requirement of beta3 adrenoceptor (beta3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and beta3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weight (BW)/12 weeks). GT-treatment attenuated final BW, BW gain, and adiposity index increased by HFD, improving insulin resistance (IR) and FGF21 level, without changing the food intake of WT mice. GT-treatment of beta3AdrKO mice attenuated only IR, denoting GT-effects independent of beta3Adr. We observed increased lipolysis accompanied by decreased adipocyte size in white adipose tissue (WAT) as well as browning of the subcutaneous WAT induced by GT in a way dependent on beta3Adr. In brown adipose tissue (BAT) mRNA levels of lipolytic/oxidative genes, including beta3Adr/Ucp1 and energy expenditure (EE) was increased by GT dependent on beta3Adr. GT-treatment increased adiponectin independent of beta3Adr. Also, independent of beta3Adr pathway GT promoted an increase in beta2Adr/Ucp1 mRNA levels and EE in BAT whereas; in the liver, GT has a dual role in increasing lipid synthesis and oxidation. These data lead us to suggest that GT uses beta3Adr pathway activation to achieve some of its beneficial health effects.
- Journal
- Pharmacol Res
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obese
- Paper Title Cn
- Paper Title En
- Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice
- Bilingual Status
- semi_complete