ReferenceID 4078
Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum Swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction
Mar Drugs
This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerni
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Record Fields
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- Reference Id
- 4078
- Evidence Id
- 20668
- Core Evidence Id
- 20668
- Source Reference Id
- 1436
- Herb2 Reference Id
- HBREF002233
- Subject Paper Key
- HERB002126_33260666
- Pubmed Id
- 33260666
- Doi
- 10.3390/md18120601
- Paper Title
- Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum Swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction
- Paper Abstract
- This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were assessed via FTIR and NMR spectroscopy. NO production stimulated by LPS was significantly declined by fucoidan. This was witnessed to be achieved via fucoidan acting on mediators such as iNOS and COX-2 including pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), with dose dependent down-regulation. Further, the effect is exhibited by the suppression of TLR mediated MyD88, IKK complex, ultimately hindering NF-kappaB and MAPK activation, proposing its therapeutic applications in inflammation related disorders. The research findings provide an insight in relation to the sustainable utilization of fucoidan from marine brown algae S. swartzii as a potent anti-inflammatory agent in the nutritional, pharmaceutical, and cosmeceutical sectors.
- Journal
- Mar Drugs
- Publish Year
- 2020
- Experiment Subject
- raw 264.7 macrophages
- Experiment Type
- Cell Experiment
- Phenotype Related
- Inflammation Related Disorders
- Paper Title Cn
- Paper Title En
- Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum Swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction
- Bilingual Status
- semi_complete