ReferenceID 4075
A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo
Nutrients
Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bio
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Record Fields
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- Reference Id
- 4075
- Evidence Id
- 20665
- Core Evidence Id
- 20665
- Source Reference Id
- 1430
- Herb2 Reference Id
- HBREF002227
- Subject Paper Key
- HERB002111_32517205
- Pubmed Id
- 32517205
- Doi
- 10.3390/nu12061698
- Paper Title
- A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo
- Paper Abstract
- Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical genes, including NF-kB, TNFalpha, iNOS, and COX-2, and attenuated inflammation and tissue damage caused by TPA in a mouse ear inflammation model. It also mitigated colonic colitis caused in mice by dextran sodium sulfate. FCS from I. badionotus of the Yucatan Peninsula thus had strong anti-inflammatory properties in vivo.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- mouse; hacat cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Attenuated Inflammation; Colonic Colitis
- Paper Title Cn
- Paper Title En
- A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo
- Bilingual Status
- semi_complete