ReferenceID 4067
Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
Nutrients
: The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts
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Record Fields
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- Reference Id
- 4067
- Evidence Id
- 20657
- Core Evidence Id
- 20657
- Source Reference Id
- 1411
- Herb2 Reference Id
- HBREF002208
- Subject Paper Key
- HERB001920_32183397
- Pubmed Id
- 32183397
- Doi
- 10.3390/nu12030773
- Paper Title
- Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
- Paper Abstract
- : The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-alpha-induced NF-kappaB transcriptional activity in the NF-kappaB luciferase assay and pro-inflammatory genes' expression by blocking phosphorylation of IkappaB and NF-kappaB in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-kappaB phosphorylation and pro-inflammatory genes' expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes' expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- mouse; 3t3-l1 adipocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Chronic Low-grade Inflammation; Metabolic Diseases; Type 2 Diabetes; Obesity
- Paper Title Cn
- Paper Title En
- Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
- Bilingual Status
- semi_complete