ReferenceID 4065
Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate
Int J Mol Sci
Colon cancer (CC) is considered a high-risk cancer in developed countries. Its etiology is correlated with a high consumption of red meat and low consumption of plant-based foods, including whole grains. Sorghum bran is
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- Reference Id
- 4065
- Evidence Id
- 20655
- Core Evidence Id
- 20655
- Source Reference Id
- 1407
- Herb2 Reference Id
- HBREF002204
- Subject Paper Key
- HERB001851_34361052
- Pubmed Id
- 34361052
- Doi
- 10.3390/ijms22158286
- Paper Title
- Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate
- Paper Abstract
- Colon cancer (CC) is considered a high-risk cancer in developed countries. Its etiology is correlated with a high consumption of red meat and low consumption of plant-based foods, including whole grains. Sorghum bran is rich in polyphenols. This study aimed to determine whether different high-phenolic sorghum brans suppress tumor formation in a genetic CC rodent model and elucidate mechanisms. Tissue culture experiments used colorectal cancer cell lines SW480, HCT-116 and Caco-2 and measured protein expression, and protein activity. The animal model used in this study was APC Min+/mouse model combined with dextram sodium sulfate. High phenolic sorghum bran extract treatment resulted in the inhibition of proliferation and induced apoptosis in CC cell lines. Treatment with high phenolic sorghum bran extracts repressed TNF-alpha-stimulated NF-kappaB transactivation and IGF-1-stimulated PI3K/AKT pathway via the downregulation of beta-catenin transactivation. Furthermore, high-phenolic sorghum bran extracts activated AMPK and autophagy. Feeding with high-phenolic sorghum bran for 6 weeks significantly suppressed tumor formation in an APC Min/+ dextran sodium sulfate promoted CC mouse model. Our data demonstrates the potential application of high-phenolic sorghum bran as a functional food for the prevention of CC.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- mouse; bran; caco-2; cc cell lines; colorectal cancer cell lines; sorghum
- Experiment Type
- Animal Experiment
- Phenotype Related
- Colon Cancer; Tumor; Colorectal Cancer; Cancer
- Paper Title Cn
- Paper Title En
- Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate
- Bilingual Status
- semi_complete