ReferenceID 4053
Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy
Nanomedicine
Recent studies have indicated that multidrug resistance (MDR) can significantly limit the effects of conventional chemotherapy. In this study, PT (Pachymic acid and dehydrotumulosic acid) are the two major triterpenoid c
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4053
- Evidence Id
- 20643
- Core Evidence Id
- 20643
- Source Reference Id
- 1387
- Herb2 Reference Id
- HBREF002184
- Subject Paper Key
- HERB001749_31669856
- Pubmed Id
- 31669856
- Doi
- 10.1016/j.nano.2019.102095
- Paper Title
- Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy
- Paper Abstract
- Recent studies have indicated that multidrug resistance (MDR) can significantly limit the effects of conventional chemotherapy. In this study, PT (Pachymic acid and dehydrotumulosic acid) are the two major triterpenoid components purified and identified in P. cocos. A liposomal co-delivery system encapsulating doxorubicin (DOX) and PT was prepared. Notably, the mechanism of PT reversed P-glycoprotein (P-gp) mediated MDR mainly relied on the inhibition of the P-gp function, which further decreased the levels of P-gp and caveolin-1 proteins. In drug-resistant MCF cells, co-administration with 5 mug/ml PT significantly enhanced sensitivity of DOX. Finally, liposome-mediated co-delivery with PT significantly improved the anti-tumor effect of DOX in tumor-bearing mice when compared to other single therapy groups. In conclusion, this study showed for the first time that DOX and PT act synergistically as an "all-in-one" treatment to reverse MDR during tumor treatment and, thus, should be studied further for a wide range of anti-cancer applications.
- Journal
- Nanomedicine
- Publish Year
- 2020
- Experiment Subject
- mouse; drug-resistant mcf cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Tumor
- Paper Title Cn
- Paper Title En
- Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy
- Bilingual Status
- semi_complete