ReferenceID 4051
Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafish
J Enzyme Inhib Med Chem
Here we investigated the effects of different levels of royal jelly in zebrafish (Danio rerio) diets [0.0% (D1); 0.1% (D2); 0.4% (D3); 1.6% (D4) vs 6.4% (D5)] on the activity and expression profiles of superoxide dismuta
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Record Fields
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- Reference Id
- 4051
- Evidence Id
- 20641
- Core Evidence Id
- 20641
- Source Reference Id
- 1385
- Herb2 Reference Id
- HBREF002182
- Subject Paper Key
- HERB001712_33752574
- Pubmed Id
- 33752574
- Doi
- 10.1080/14756366.2021.1900167
- Paper Title
- Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafish
- Paper Abstract
- Here we investigated the effects of different levels of royal jelly in zebrafish (Danio rerio) diets [0.0% (D1); 0.1% (D2); 0.4% (D3); 1.6% (D4) vs 6.4% (D5)] on the activity and expression profiles of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione S-transferase. Muscle, liver and kidney tissue samples were obtained from fish fed during 8 weeks. In these tissues, enzyme activity was determined by means of spectrophotometer and gene expression by quantitative real-time PCR. mRNA levels of the enzymes were elevated in almost all diet groups compared to the control (D1). It was determined that enzyme activities were also increased in general by supplementation of royal jelly although some decreases were also observed. However, the significant correlation between gene expression and enzyme activity was not observed in all tissues. It was concluded that main regulation occurs with post-translational modifications although effects at transcriptomic level demonstrated a snap variation.
- Journal
- J Enzyme Inhib Med Chem
- Publish Year
- 2021
- Experiment Subject
- zebrafish
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafish
- Bilingual Status
- semi_complete