ReferenceID 405
Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
J Exp Clin Cancer Res
BACKGROUND: Twist1 is involved in tumor initiation and progression, which especially contributes to tumor invasion and metastasis. Wogonoside is the main in-vivo metabolite of wogonin, and it is also a natural product wi
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Record Fields
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- Reference Id
- 405
- Evidence Id
- 16995
- Core Evidence Id
- 16995
- Source Reference Id
- 780
- Herb2 Reference Id
- HBREF001345
- Subject Paper Key
- HBIN048376_28774312
- Pubmed Id
- 28774312
- Doi
- 10.1186/s13046-017-0574-5
- Paper Title
- Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
- Paper Abstract
- BACKGROUND: Twist1 is involved in tumor initiation and progression, which especially contributes to tumor invasion and metastasis. Wogonoside is the main in-vivo metabolite of wogonin, and it is also a natural product with potential treatment effects against cancer. METHODS: In this study, we investigated the in-vitro anti-invasion and in-vivo anti-metastasis effects of wogonoside on breast cancer cells and uncovered its underlying mechanism. RESULTS: The results showed that wogonoside could suppress the growth and metastasis of breast tumor in the orthotopic model of MDA-MB-231 cells. We found that wogonoside could reduce the overexpression of TNF-α, TRAF2 and TRAF4 in later stage of tumor, and improved tumor microenvironment. Therefore, TNF-α was utilized to induce metastases of breast cancer cell in vitro. Wogonoside could inhibit invasion and migration in TNF-α-induced MDA-MB-231, MDA-MB-435, and BT-474 cells. Mechanically, wogonoside inactivated NF-κB signaling through decreasing the protein expression of TRAF2/4, which further inhibited Twist1 expression. Consequently, wogonoside could down-regulate MMP-9, MMP-2, vimentin and CD44v6 expression in TNF-α-induced MDA-MB-231 and MDA-MB-435 cells. Then, these findings were proved in TNF-α + TGF-β1-induced MCF7 cells. CONCLUSIONS: Wogonoside might be a potential therapeutic agent for the treatment of tumor metastasis in breast cancer.
- Journal
- J Exp Clin Cancer Res
- Publish Year
- 2017
- Experiment Subject
- breast cancer cells,mda-mb-231 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Breast Cancer
- Paper Title Cn
- Paper Title En
- Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
- Bilingual Status
- semi_complete