ReferenceID 4017
Hepatoprotective Effect of Citrus aurantium L. Against APAP-induced Liver Injury by Regulating Liver Lipid Metabolism and Apoptosis
Int J Biol Sci
Acetaminophen (APAP) refers to a medication used to manage pain and fever symptoms, but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus aurantium L., is a famous Citrus herbal medicine i
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Record Fields
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- Reference Id
- 4017
- Evidence Id
- 20607
- Core Evidence Id
- 20607
- Source Reference Id
- 1318
- Herb2 Reference Id
- HBREF002115
- Subject Paper Key
- HERB001171_32071546
- Pubmed Id
- 32071546
- Doi
- 10.7150/ijbs.40612
- Paper Title
- Hepatoprotective Effect of Citrus aurantium L. Against APAP-induced Liver Injury by Regulating Liver Lipid Metabolism and Apoptosis
- Paper Abstract
- Acetaminophen (APAP) refers to a medication used to manage pain and fever symptoms, but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus aurantium L., is a famous Citrus herbal medicine in Asian countries which is rich in dietary phenolic substances. In this study, the mechanism of Zhishi protected against APAP-induced liver injury was studied more deeply by metabolomic strategy and pharmacological study. The metabolomics results demonstrated that Zhishi can prevent the APAP-induced liver injury model by regulating liver metabolic disorders in glycerophospholipid metabolism, fatty acid biosynthesis and glycerolipid metabolism. Moreover, it is confirmed that Zhishi blocked apoptosis of APAP-induced BRL-3A cell by simultaneously regulating p53 up-regulated apoptosis regulator (PUMA), AMPK-SIRT1 and JNK1 signaling pathways. Our findings indicated that Zhishi exhibited a hepaprotective effect against APAP-induced liver necrosis by inhibiting the PUMA and reversing disorder of liver lipid metabolism which could assist in improving the clinical outcomes of chemical-induced liver injury.
- Journal
- Int J Biol Sci
- Publish Year
- 2020
- Experiment Subject
- apap-induced brl-3a cell
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Disorder Of Liver Lipid Metabolism; Liver Injury; Liver Metabolic Disorders; Fever
- Paper Title Cn
- Paper Title En
- Hepatoprotective Effect of Citrus aurantium L. Against APAP-induced Liver Injury by Regulating Liver Lipid Metabolism and Apoptosis
- Bilingual Status
- semi_complete