ReferenceID 4
The effects of Spirulina on anemia and immune function in senior citizens
Cell Mol Immunol
Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-gre
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4
- Evidence Id
- 16594
- Core Evidence Id
- 16594
- Source Reference Id
- 10
- Herb2 Reference Id
- HBREF000023
- Subject Paper Key
- HERB003610_21278762
- Pubmed Id
- 21278762
- Doi
- 10.1038/cmi.2010.76
- Paper Title
- The effects of Spirulina on anemia and immune function in senior citizens
- Paper Abstract
- Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects. We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia. We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases. Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study. Complete cell count (CCC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity, as a sign of immune function, were determined at baseline and weeks 6 and 12 of supplementation. Thirty study participants completed the entire study and the data obtained were analyzed. Over the 12-week study period, there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes. In addition, mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants. Older women appeared to benefit more rapidly from Spirulina supplements. Similarly, the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation. Spirulina may ameliorate anemia and immunosenescence in older subjects. We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.
- Journal
- Cell Mol Immunol
- Publish Year
- 2011
- Experiment Subject
- 50 years or older volunteers
- Experiment Type
- Clinical Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- The effects of Spirulina on anemia and immune function in senior citizens
- Bilingual Status
- semi_complete