ReferenceID 3978
Scrophularia buergeriana attenuates allergic inflammation by reducing NF-κB activation
Phytomedicine
BACKGROUND: Scrophularia buergeriana Miq. (Scrophulariaceae) (SB) has been used as an oriental medicine for the treatment of inflammatory diseases, such as neuritis and pharyngolaryngitis. PURPOSE: We explored the therap
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Record Fields
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- Reference Id
- 3978
- Evidence Id
- 20568
- Core Evidence Id
- 20568
- Source Reference Id
- 1229
- Herb2 Reference Id
- HBREF002026
- Subject Paper Key
- HERB000410_31901567
- Pubmed Id
- 31901567
- Doi
- 10.1016/j.phymed.2019.153159
- Paper Title
- Scrophularia buergeriana attenuates allergic inflammation by reducing NF-κB activation
- Paper Abstract
- BACKGROUND: Scrophularia buergeriana Miq. (Scrophulariaceae) (SB) has been used as an oriental medicine for the treatment of inflammatory diseases, such as neuritis and pharyngolaryngitis. PURPOSE: We explored the therapeutic effects of S. buergeriana ethanol extract (SBE) on airway inflammation in ovalbumin (OVA)-induced asthmatic mice and lipopolysaccharide (LPS)-stimulated RAW264.7 cells. METHODS: Mice were intraperitoneally injected with OVA on days 0 and 14 to elevate the immune response. On days 21 to 23, the mice were challenged with OVA solution and SBE (20 and 40 mg/kg) was administered daily by oral gavage from days 18 to 23. RAW264.7 cells were pretreated with SBE 1 h before LPS stimulation. RESULTS: SBE administration effectively suppressed inflammatory cell infiltration, the expression of interleukin (IL)-5, IL-13, and IL-17, immunoglobulin E, and airway hyperresponsiveness in an OVA-induced allergic asthma model. A reduction in histological alterations, including airway inflammation and mucus hypersecretion, was observed. These effects of SBE were accompanied by a decrease in matrix metalloproteinase-9 (MMP-9) expression and nuclear factor kappa B (NF-kappaB) phosphorylation. These responses were observed in LPS-stimulated RAW264.7 cells. SBE treatment reduced the mRNA expression of tumor necrosis factor (TNF)-alpha, IL-6, and MMP-9, and NF-kappaB phosphorylation, in LPS-stimulated RAW264.7 cells. CONCLUSION: Our results indicated that SBE effectively attenuated airway inflammation in an OVA-induced allergic asthma model. These properties of SBE were thought to be involved in the suppression of NF-kappaB phosphorylation, suggesting that the material has the potential to regulate the development of allergic asthma.
- Journal
- Phytomedicine
- Publish Year
- 2020
- Experiment Subject
- mouse; lipopolysaccharide (lps)-stimulated raw264.7 cells; lps-stimulated raw264.7 cells; raw264.7 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Airway Hyperresponsiveness; Inflammatory Diseases; Ova-induced Allergic Asthma; Tumor; Attenuated Airway Inflammation; Neuritis; Pharyngolaryngitis; Airway Inflammation; Mucus Hypersecretion; Allergic Asthma
- Paper Title Cn
- Paper Title En
- Scrophularia buergeriana attenuates allergic inflammation by reducing NF-κB activation
- Bilingual Status
- semi_complete