ReferenceID 3971
Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats
Front Pharmacol
Ethnopharmacological relevance: Serpylli herba extract (SHE), composed of the aerial parts of wild thyme ( Thymus serpyllum L.) ( Lamiaceae family), is traditionally used in Europe and North Africa to treat diarrhea, gas
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Record Fields
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- Reference Id
- 3971
- Evidence Id
- 20561
- Core Evidence Id
- 20561
- Source Reference Id
- 1217
- Herb2 Reference Id
- HBREF002014
- Subject Paper Key
- HERB000233_36120292
- Pubmed Id
- 36120292
- Doi
- 10.3389/fphar.2022.967644
- Paper Title
- Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats
- Paper Abstract
- Ethnopharmacological relevance: Serpylli herba extract (SHE), composed of the aerial parts of wild thyme ( Thymus serpyllum L.) ( Lamiaceae family), is traditionally used in Europe and North Africa to treat diarrhea, gastric ulcers, intestinal parasites and upper respiratory tract infections. Recently, SHE has generated a great interest for irritable bowel syndrome (IBS) management, probably due to its intestinal anti-inflammatory properties shown in experimental colitis and the fact that its active components could preserve the intestinal barrier integrity, which is altered in patients with IBS. Aim of study: We aimed to test the effects of a SHE in a rat experimental model resembling human IBS. Materials and methods: IBS was provoked by deoxycholic acid (DCA). Rats were then treated with SHE (100 mg/kg) or gabapentin (70 mg/kg) and different inflammatory and gut barrier integrity markers were evaluated. Moreover, several gut hypersensitivity and hyperalgesia determinations were performed. Results: SHE improved referred pain and visceral hypersensitivity. Additionally, SHE enhanced immune status by downregulating of the expression of the pro-inflammatory mediators Il-1β, Il-6, Ifn-γ, Tlr-4, and the inducible enzyme Cox-2 , thus inducing visceral analgesia, and promoting the restore of the gut barrier function by upregulating the mucins Muc-2 and Muc-3 . These anti-inflammatory effects could be related to its action on mast cells since it significantly inhibited the β -Hexosaminidase production in RBL-2H3 cells. Lastly, SHE also seems to modulate the serotonin pathway by restoring the altered expression of the 5-HT receptors Htr-3 and Htr-4 . Conclusion: SHE could be considered a potential new treatment for IBS, since it ameliorates hypersensitivity, visceral hyperalgesia, and inflammation. These beneficial effects may be due to the inhibition of mast cells degranulation and serotonin pathway.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- rat; human; patient; rbl-2h3 cells; thyme
- Experiment Type
- Animal Experiment
- Phenotype Related
- Inflammation; Hypersensitivity And Hyperalgesia; Colitis; Visceral Hypersensitivity; Diarrhea; Upper Respiratory Tract Infections; Irritable Bowel Syndrome; Visceral Hyperalgesia; Gastric Ulcers
- Paper Title Cn
- Paper Title En
- Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats
- Bilingual Status
- semi_complete