ReferenceID 3965
A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract ( Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
Nutrients
(1) Background: Due to its richness in chlorogenic acids (CGAs), Mate (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This tria
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3965
- Evidence Id
- 20555
- Core Evidence Id
- 20555
- Source Reference Id
- 1206
- Herb2 Reference Id
- HBREF002003
- Subject Paper Key
- HERB000140_33374524
- Pubmed Id
- 33374524
- Doi
- 10.3390/nu13010014
- Paper Title
- A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract ( Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
- Paper Abstract
- (1) Background: Due to its richness in chlorogenic acids (CGAs), Mate (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This trial aimed to evaluate the impact of mate CGAs, consumed in a daily dose achievable through traditional mate beverages, on parameters related to cardiometabolic risk. (2) Design: Thirty-four male volunteers aged 45-65 years and with at most one criteria of metabolic syndrome, were recruited for a randomized, double-blind, placebo-controlled, and crossover study. The volunteers were assigned to consume an encapsulated dry mate extract for four-weeks, providing 580 mg of caffeoyl quinic acid derivatives (CQAs) daily, or a placebo, with a two weeks washout between intervention periods. Anthropometric variables, blood pressure, plasma glucose, lipids, endothelial, and inflammatory biomarkers were measured in overnight-fasted subjects and after a glucose load. (3) Results: We found no significant effects of treatment on these parameters and the response to the glucose load was also similar between the two interventions. However, a significant decrease in fasting glucose was observed between day 0 and day 28 for the mate group only (-0.57 +- 0.11 mmol/L, p < 0.0002). In subjects with an intermediate to high Framingham risk score, consumption of mate extract induced a 10% increase of high-density lipoprotein (HDL)-c from baseline. In a subgroup representative of the study population, significant decreases in the C-reactive protein (CRP) (-50%) and interleukin-6 (IL-6) (-19%) levels were observed. (4) Conclusions: These clinical observations suggest that mate, naturally rich in CGAs, could improve some cardiometabolic markers in subjects with a higher predisposition to metabolic syndrome, even if that remains to be confirmed in new trials specifically targeting this population.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Clinical Experiment
- Phenotype Related
- Metabolic Syndrome; Cardiometabolic Diseases
- Paper Title Cn
- Paper Title En
- A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract ( Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
- Bilingual Status
- semi_complete