ReferenceID 3928
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Nat Commun
Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3
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Record Fields
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- Reference Id
- 3928
- Evidence Id
- 20518
- Core Evidence Id
- 20518
- Source Reference Id
- 1125
- Herb2 Reference Id
- HBREF001905
- Subject Paper Key
- HBIN006552_27009967
- Pubmed Id
- 27009967
- Doi
- 10.1038/ncomms10959
- Paper Title
- Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
- Paper Abstract
- Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic.
- Journal
- Nat Commun
- Publish Year
- 2016
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
- Bilingual Status
- semi_complete