ReferenceID 3873
Prdm4 induction by the small molecule butein promotes white adipose tissue browning
Nat Chem Biol
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molec
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3873
- Evidence Id
- 20463
- Core Evidence Id
- 20463
- Source Reference Id
- 1037
- Herb2 Reference Id
- HBREF001764
- Subject Paper Key
- HBIN019083_27159578
- Pubmed Id
- 27159578
- Doi
- 10.1038/nchembio.2081
- Paper Title
- Prdm4 induction by the small molecule butein promotes white adipose tissue browning
- Paper Abstract
- Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
- Journal
- Nat Chem Biol
- Publish Year
- 2016
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity
- Paper Title Cn
- Paper Title En
- Prdm4 induction by the small molecule butein promotes white adipose tissue browning
- Bilingual Status
- semi_complete