ReferenceID 3865
Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy
FASEB J
Colorectal cancer (CRC) is one of the most prevalent neoplastic diseases worldwide, and effective treatment remains a challenge. Here, we found that the macrolide antibiotic brefeldin A (BFA) exhibits considerable antitu
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3865
- Evidence Id
- 20455
- Core Evidence Id
- 20455
- Source Reference Id
- 1015
- Herb2 Reference Id
- HBREF001736
- Subject Paper Key
- HBIN018821_30668917
- Pubmed Id
- 30668917
- Doi
- 10.1096/fj.201801983R
- Paper Title
- Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy
- Paper Abstract
- Colorectal cancer (CRC) is one of the most prevalent neoplastic diseases worldwide, and effective treatment remains a challenge. Here, we found that the macrolide antibiotic brefeldin A (BFA) exhibits considerable antitumor activity both in vitro and in vivo. Induction of complete autophagic flux is characterized as a key event in BFA-induced CRC suppression. Mechanistically, BFA provokes endoplasmic reticulum stress-mediated binding immunoglobulin protein (Bip) expression, leading to increased Bip/Akt interaction and resultant decreased Akt phosphorylation, thereby activating autophagy. Autophagy inhibition or Bip suppression relieves BFA-induced cell death, suggesting a key role for Bip-regulated autophagy in the antitumor properties of BFA. Moreover, BFA acts synergistically with paclitaxel or 5-fluorouracil in CRC suppression. Collectively, our study provides an important molecular basis for BFA-induced autophagy and suggests that the antibiotic BFA could be repositioned as a potential anticancer drug for CRC treatment.-Zhou, L., Gao, W., Wang, K., Huang, Z., Zhang, L., Zhang, Z., Zhou, J., Nice, E. C., Huang, C. Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy.
- Journal
- FASEB J
- Publish Year
- 2019
- Experiment Subject
- Experiment Type
- Others
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy
- Bilingual Status
- semi_complete