ReferenceID 3684
The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
J Exp Clin Cancer Res
BACKGROUND: Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many typ
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3684
- Evidence Id
- 20274
- Core Evidence Id
- 20274
- Source Reference Id
- 656
- Herb2 Reference Id
- HBREF001098
- Subject Paper Key
- HBIN046110_29334999
- Pubmed Id
- 29334999
- Doi
- 10.1186/s13046-018-0678-6
- Paper Title
- The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
- Paper Abstract
- BACKGROUND: Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types of cancer cells. In this study, we investigated the effects of tetrandrine on human hepatocellular carcinoma (HCC) metastasis. METHODS: The invasion and migration effects were evaluated via wound healing and transwell assays. Immunofluorescence and western blotting analyses were used to investigate the levels of epithelial-mesenchymal transition (EMT)-related protein. A metastasis model was established to investigate the inhibitory effect of tetrandrine on hepatocellular carcinoma metastasis in vivo. RESULTS: Tetrandrine inhibits HCC invasion and migration by preventing cell EMT. The underlying mechanism was closely associated with tetrandrine-induced human liver cell autophagy, which inhibits Wnt/β-catenin pathway activity and decreases metastatic tumor antigen 1 (MTA1) expression to modulate cancer cell metastasis. CONCLUSION: Our findings demonstrate, for the first time, that tetrandrine plays a significant role in the inhibition of human hepatocellular carcinoma metastasis and provide novel insights into the application of tetrandrine in clinical HCC treatment.
- Journal
- J Exp Clin Cancer Res
- Publish Year
- 2018
- Experiment Subject
- hepatocellular cancer cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Hepatocellular Carcinoma Metastasis
- Paper Title Cn
- Paper Title En
- The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
- Bilingual Status
- semi_complete