ReferenceID 3673
β-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents
Br J Pharmacol
BACKGROUND AND PURPOSE: Beta-caryophyllene (BCP) is a dietary plant-derived terpenoid that has been used as a food additive for many decades. Recent studies indicate that BCP is a cannabinoid CB2 receptor (CB2R) agonist
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Record Fields
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- Reference Id
- 3673
- Evidence Id
- 20263
- Core Evidence Id
- 20263
- Source Reference Id
- 633
- Herb2 Reference Id
- HBREF001072
- Subject Paper Key
- HBIN019817_31883107
- Pubmed Id
- 31883107
- Doi
- 10.1111/bph.14969
- Paper Title
- β-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents
- Paper Abstract
- BACKGROUND AND PURPOSE: Beta-caryophyllene (BCP) is a dietary plant-derived terpenoid that has been used as a food additive for many decades. Recent studies indicate that BCP is a cannabinoid CB2 receptor (CB2R) agonist with medical benefits for a number of human diseases. However, little is known about its therapeutic potential for drug abuse and addiction. EXPERIMENTAL APPROACH: We used pharmacological, transgenic, and optogenetic approaches to systematically evaluate the effects of BCP on nicotine-taking and nicotine-seeking behavior in animal models of drug self-administration, electrical and optical brain-stimulation reward. KEY RESULTS: Systemic administration of BCP dose-dependently inhibited nicotine self-administration and motivation for nicotine seeking in rats and mice. The reduction in nicotine self-administration was blocked by AM630, a selective CB2R antagonist, but not by AM251, a selective CB1R antagonist, suggesting the involvement of a CB2R mechanism. Genetic deletion of CB2Rs in CB2-knockout mice blocked the reduction in nicotine self-administration produced only by low doses, but not high doses, of BCP, suggesting the involvement of both CB2 and non-CB2 receptor mechanisms. Furthermore, in the intracranial self-stimulation paradigm, BCP attenuated electrical brain-stimulation reward (BSR) and nicotine-enhanced BSR in rats. Lastly, BCP also attenuated BSR maintained by optogenetic stimulation of dopamine (DA) neurons in the ventral tegmental area in DAT-cre mice, suggesting the involvement of a DA-dependent mechanism in BCP's action. CONCLUSIONS AND IMPLICATIONS: The present findings suggest that BCP has significant anti-nicotine effects via both CB2 and non-CB2 receptor mechanisms, and therefore, deserves further study as a potential new pharmacotherapy for cigarette smoking cessation.
- Journal
- Br J Pharmacol
- Publish Year
- 2019
- Experiment Subject
- mouse; rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- β-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents
- Bilingual Status
- semi_complete