ReferenceID 3604
Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation
J Bone Miner Res
Bone remodeling, a physiological process in which new bone is formed by osteoblasts and the preexisting bone matrix is resorbed by osteoclasts, is vital for the maintenance of healthy bone tissue in adult humans. Imbala
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- Reference Id
- 3604
- Evidence Id
- 20194
- Core Evidence Id
- 20194
- Source Reference Id
- 505
- Herb2 Reference Id
- HBREF000851
- Subject Paper Key
- HBIN025042_25832436
- Pubmed Id
- 25832436
- Doi
- 10.1002/jbmr.2183
- Paper Title
- Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation
- Paper Abstract
- Bone remodeling, a physiological process in which new bone is formed by osteoblasts and the preexisting bone matrix is resorbed by osteoclasts, is vital for the maintenance of healthy bone tissue in adult humans. Imbalances in this process can cause various pathological conditions, including osteoporosis. Emodin, a naturally occurring anthraquinone derivative found in Asian herbal medicines, has numerous beneficial pharmacologic effects, including anticancer and antidiabetic activities. However, the effect of emodin on the regulation of osteoblast and osteoclast activity has not yet been investigated. We show here that emodin is a potential target for osteoporosis therapeutics, as treatment with this agent enhances osteoblast differentiation and bone growth and suppresses osteoclast differentiation and bone resorption. In this study, emodin suppressed receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclast differentiation of bone marrow macrophages (BMMs) and the bone-resorbing activity of mature osteoclasts by inhibiting RANKL-induced NF-κB, c-Fos, and NFATc1 expression. Emodin also increased ALP, Alizarin Red-mineralization activity, and the expression of osteoblastogenic gene markers, such as Runx2, osteocalcin (OCN), and ALP in mouse calvarial primary osteoblasts, as well as activated the p38-Runx2 pathway, which enhanced osteoblast differentiation. Moreover, mice treated with emodin showed marked attenuation of lipopolysaccharide (LPS)-induced bone erosion and increased bone-forming activity in a mouse calvarial bone formation model based on micro-computed tomography and histologic analysis of femurs. Our findings reveal a novel function for emodin in bone remodeling, and highlight its potential for use as a therapeutic agent in the treatment of osteoporosis that promotes bone anabolic activity and inhibits osteoclast differentiation.
- Journal
- J Bone Miner Res
- Publish Year
- 2014
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Osteoporosis
- Paper Title Cn
- Paper Title En
- Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation
- Bilingual Status
- semi_complete