ReferenceID 3602
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells
Cell Death Dis
Hispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. However, the molecular mechanism involved in hispolon-mediated tumor-suppressing activities observed i
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3602
- Evidence Id
- 20192
- Core Evidence Id
- 20192
- Source Reference Id
- 503
- Herb2 Reference Id
- HBREF000849
- Subject Paper Key
- HBIN029437_28981104
- Pubmed Id
- 28981104
- Doi
- 10.1038/cddis.2017.459
- Paper Title
- Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells
- Paper Abstract
- Hispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. However, the molecular mechanism involved in hispolon-mediated tumor-suppressing activities observed in cervical cancer is poorly characterized. Here, we demonstrated that treatment with hispolon inhibited cell metastasis in two cervical cancer cell lines. In addition, the downregulation of the lysosomal protease Cathepsin S (CTSS) was critical for hispolon-mediated suppression of tumor cell metastasis in both in vitro and in vivo models. Moreover, hispolon induced autophagy, which increased LC3 conversion and acidic vesicular organelle formation. Mechanistically, hispolon inhibited the cell motility of cervical cells through the extracellular signal-regulated kinase (ERK) pathway, and blocking of the ERK pathway reversed autophagy-mediated cell motility and CTSS inhibition. Our results indicate that autophagy is essential for decreasing CTSS activity to inhibit tumor metastasis by hispolon treatment in cervical cancer; this finding provides a new perspective on molecular regulation.
- Journal
- Cell Death Dis
- Publish Year
- 2017
- Experiment Subject
- cervical cancer cell lines
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells
- Bilingual Status
- semi_complete