ReferenceID 3579
Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway
Cell Biol Toxicol
Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol in the gastrointestinal tract by digestive enzymes. These compounds have been shown to h
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Record Fields
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- Reference Id
- 3579
- Evidence Id
- 20169
- Core Evidence Id
- 20169
- Source Reference Id
- 461
- Herb2 Reference Id
- HBREF000789
- Subject Paper Key
- HBIN026808_24760606
- Pubmed Id
- 24760606
- Doi
- 10.1007/s10565-014-9277-2
- Paper Title
- Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway
- Paper Abstract
- Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol in the gastrointestinal tract by digestive enzymes. These compounds have been shown to have many beneficial health effects. The present study was designed to evaluate the molecular mechanisms of action of fucoxanthin and/or of its metabolite fucoxanthinol against viability of estrogen-sensitive MCF-7 and estrogen-resistant MDA-MB-231 breast cancer cell lines. Fucoxanthin and fucoxanthinol reduced the viability of MCF-7 and MDA-MB-231 cells in dose- and time-dependent manners as a result of increased apoptosis. Furthermore, fucoxanthinol-induced apoptosis was more potent than that of fucoxanthin and correlated, for MDA-MB-231 cells, with inhibitory actions on members of the NF-κB pathway p65, p50, RelB, and p52. Being overexpressed and regulated by NF-κB in different types of cancers, the transcription factor SOX9 was also decreased at the nuclear level by fucoxanthin and fucoxanthinol in MDA-MB-231. Taken together, the current results suggest that fucoxanthinol and fucoxanthin could be potentially effective for the treatment and/or prevention of different types of cancers, including breast cancer.
- Journal
- Cell Biol Toxicol
- Publish Year
- 2014
- Experiment Subject
- estrogen-sensitive mcf-7 and estrogen-resistant mda-mb-231 breast cancer cell lines
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cancers || Breast Cancer
- Paper Title Cn
- Paper Title En
- Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway
- Bilingual Status
- semi_complete