ReferenceID 3576
Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells
Cancer Lett
Previously, we demonstrated that diosgenin induced apoptosis in colorectal cancer cell lines HCT-116 and HT-29. HT-29 cells have been reported to be one of the most resistant colorectal cancer cell lines to TRAIL-induced
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3576
- Evidence Id
- 20166
- Core Evidence Id
- 20166
- Source Reference Id
- 456
- Herb2 Reference Id
- HBREF000779
- Subject Paper Key
- HBIN024164_21195543
- Pubmed Id
- 21195543
- Doi
- 10.1016/j.canlet.2010.12.003
- Paper Title
- Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells
- Paper Abstract
- Previously, we demonstrated that diosgenin induced apoptosis in colorectal cancer cell lines HCT-116 and HT-29. HT-29 cells have been reported to be one of the most resistant colorectal cancer cell lines to TRAIL-induced apoptosis. In this study, we investigated the effect of diosgenin on TRAIL-induced apoptosis in HT-29 cells. We showed that diosgenin sensitizes HT-29 cells to TRAIL-induced apoptosis. Mechanisms underlying this sensitization mainly involved diosgenin-induced p38 MAPK pathway activation and subsequent DR5 overexpression. Furthermore, we showed that diosgenin alone, TRAIL alone or combination treatment increased COX-2 expression and that the use of a COX-2 inhibitor further increased apoptosis induction.
- Journal
- Cancer Lett
- Publish Year
- 2011
- Experiment Subject
- colorectal cancer cell lines hct-116 and ht-29
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells
- Bilingual Status
- semi_complete