ReferenceID 3542
Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
Acta Pharm Sin B
The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., i
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Record Fields
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- Reference Id
- 3542
- Evidence Id
- 20132
- Core Evidence Id
- 20132
- Source Reference Id
- 391
- Herb2 Reference Id
- HBREF000699
- Subject Paper Key
- HBIN020479_31384538
- Pubmed Id
- 31384538
- Doi
- 10.1016/j.apsb.2018.10.008
- Paper Title
- Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
- Paper Abstract
- The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes. However, the effects of CHR s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide (3AB) and ABT888. Ectopic expression of PARP1 effectively blocked this CHR s cardioprotection against DOX-induced cardiomyocyte injury in H9C2 cells. Furthermore, pre-administration with both CHR and 3AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague-Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy.
- Journal
- Acta Pharm Sin B
- Publish Year
- 2019
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cardiomyocyte Injury
- Paper Title Cn
- Paper Title En
- Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
- Bilingual Status
- semi_complete