ReferenceID 3480
A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer
Cancer Lett
In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony f
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Record Fields
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- Reference Id
- 3480
- Evidence Id
- 20070
- Core Evidence Id
- 20070
- Source Reference Id
- 259
- Herb2 Reference Id
- HBREF000497
- Subject Paper Key
- HBIN022961_23348700
- Pubmed Id
- 23348700
- Doi
- 10.1016/j.canlet.2013.01.022
- Paper Title
- A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer
- Paper Abstract
- In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling activation, and up-regulation of IGF-binding protein-3 (IGFBP-3) expression may be associated with deguelin-mediated antitumor effects. Our findings suggest a potential therapeutic use for deguelin in patients with triple-negative breast cancer and for those with breast cancers who are sensitive to endocrine- and HER2-targeted therapies.
- Journal
- Cancer Lett
- Publish Year
- 2013
- Experiment Subject
- triple-negative (mda-mb-231 and mda-mb-468) and triple-positive (mcf-7) breast cancer cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Breast Cancer
- Paper Title Cn
- Paper Title En
- A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer
- Bilingual Status
- semi_complete