ReferenceID 3478
Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway
Cancer Lett
Recent reports have indicated that decursin can induce apoptosis, suppress tumor growth, and inhibit angiogenesis. In this experiment, we investigated how decursin could potentiate the cytotoxic effects of bortezomib in
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Record Fields
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- Reference Id
- 3478
- Evidence Id
- 20068
- Core Evidence Id
- 20068
- Source Reference Id
- 257
- Herb2 Reference Id
- HBREF000494
- Subject Paper Key
- HBIN022938_21122982
- Pubmed Id
- 21122982
- Doi
- 10.1016/j.canlet.2010.11.002
- Paper Title
- Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway
- Paper Abstract
- Recent reports have indicated that decursin can induce apoptosis, suppress tumor growth, and inhibit angiogenesis. In this experiment, we investigated how decursin could potentiate the cytotoxic effects of bortezomib in human multiple myeloma cells. We found that decursin inhibited cell viability in U266, MM.1S and ARH77 cells, but not in peripheral blood mononuclear cells (PBMC). Decursin-induced apoptosis through the activation of caspase-8, -9, and -3 in U266 cells. This correlated with the down-regulating of cyclin D1, bcl-2, bcl-xL, survivin, and the vascular endothelial growth factor (VEGF), which are all regulated by the activation of signal transducers and the activator of transcription 3 (STAT3). Indeed, decursin inhibited constitutive STAT3 activation through inhibition of the activation of Janus-activated kinase 2 (JAK2) in U266 cells. In addition, decursin inhibited interleukin-6-inducible STAT3 activation in a time-dependent manner in MM.1S cells. Interestingly, decursin significantly potentiated the apoptotic effects of bortezomib in U266 cells. These effects of decursin were correlated with the suppression of constitutive STAT3 activation in U266 cells. Overall, these results suggest that decursin is a novel blocker of STAT3 activation and it may be a potential candidate for overcoming chemo-resistance through suppression of this signaling.
- Journal
- Cancer Lett
- Publish Year
- 2011
- Experiment Subject
- human multiple myeloma cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway
- Bilingual Status
- semi_complete