ReferenceID 3467
A novel analgesic isolated from a traditional Chinese medicine
Curr Biol
BACKGROUND: Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 3467
- Evidence Id
- 20057
- Core Evidence Id
- 20057
- Source Reference Id
- 261
- Herb2 Reference Id
- HBREF000499
- Subject Paper Key
- HBIN022997_24388848
- Pubmed Id
- 24388848
- Doi
- 10.1016/j.cub.2013.11.039
- Paper Title
- A novel analgesic isolated from a traditional Chinese medicine
- Paper Abstract
- BACKGROUND: Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the "herbalome" project, with the reverse pharmacology approach aimed at discovering new endogenous transmitters and hormones. RESULTS: In a plant used for centuries for its analgesic properties, we identify a compound, dehydrocorybulbine (DHCB), that is effective at alleviating thermally induced acute pain. We synthesize DHCB and show that it displays moderate dopamine receptor antagonist activities. By using selective pharmacological compounds and dopamine receptor knockout (KO) mice, we show that DHCB antinociceptive effect is primarily due to its interaction with D2 receptors, at least at low doses. We further show that DHCB is effective against inflammatory pain and injury-induced neuropathic pain and furthermore causes no antinociceptive tolerance. CONCLUSIONS: Our study casts DHCB as a different type of analgesic compound and as a promising lead in pain management.
- Journal
- Curr Biol
- Publish Year
- 2014
- Experiment Subject
- knockout (ko) mice
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- A novel analgesic isolated from a traditional Chinese medicine
- Bilingual Status
- semi_complete