ReferenceID 3443
Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage
Brain Behav Immun
Intracerebral haemorrhage (ICH) induces inflammation, which can cause severe secondary injury. Recent evidence has suggested that magnolol (MG) has a protective effect against ischaemic stroke through the inhibition of i
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Record Fields
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- Reference Id
- 3443
- Evidence Id
- 20033
- Core Evidence Id
- 20033
- Source Reference Id
- 192
- Herb2 Reference Id
- HBREF000381
- Subject Paper Key
- HBIN034250_30597199
- Pubmed Id
- 30597199
- Doi
- 10.1016/j.bbi.2018.12.018
- Paper Title
- Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage
- Paper Abstract
- Intracerebral haemorrhage (ICH) induces inflammation, which can cause severe secondary injury. Recent evidence has suggested that magnolol (MG) has a protective effect against ischaemic stroke through the inhibition of inflammation. However, the anti-inflammatory effect of MG in intracerebral haemorrhage (ICH) remains unclear. Here, we report that the protective effect of MG in a rat model of ICH can be achieved by anti-inflammatory processes. We found that MG administration significantly reduced the brain water content, restored the blood-brain barrier (BBB) and subsequently attenuated neurological deficits via decreasing the activation of glial cells, decreasing the infiltration of neutrophils and reducing the production of pro-inflammation factors (IL-1β, TNF-α and MMP-9) in a rat model of ICH. These results suggest that MG reduced inflammatory injury and improved neurological outcomes in ICH model.
- Journal
- Brain Behav Immun
- Publish Year
- 2019
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage
- Bilingual Status
- semi_complete