ReferenceID 3431
Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells
Cancer Lett
Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin f
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- Reference Id
- 3431
- Evidence Id
- 20021
- Core Evidence Id
- 20021
- Source Reference Id
- 162
- Herb2 Reference Id
- HBREF000337
- Subject Paper Key
- HBIN038752_29061506
- Pubmed Id
- 29061506
- Doi
- 10.1016/j.canlet.2017.10.013
- Paper Title
- Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells
- Paper Abstract
- Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Panaxynol inhibited the sphere forming ability of NSCLC CSCs at nanomolar concentrations, and micromolar concentrations of panaxynol suppressed the viability of NSCLC cells (non-CSCs) and their sublines carrying acquired chemoresistance with minimal effect on normal cells derived from various organs. Orally administered panaxynol significantly reduced lung tumorigenesis in KrasG12D/+ transgenic mice and mice carrying NSCLC xenografts without detectable toxicity. Mechanistically, panaxynol disrupted Hsp90 function by binding to the N-terminal and C-terminal ATP-binding pockets of Hsp90 without increasing Hsp70 expression. These data suggest the potential of panaxynol as a natural Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities.
- Journal
- Cancer Lett
- Publish Year
- 2018
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells
- Bilingual Status
- semi_complete