ReferenceID 3359
Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1
Acta Pharm Sin B
As a leading cause of respiratory disease, influenza A virus (IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for
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Record Fields
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- Reference Id
- 3359
- Evidence Id
- 19949
- Core Evidence Id
- 19949
- Source Reference Id
- 6
- Herb2 Reference Id
- HBREF000012
- Subject Paper Key
- HERB006570_29159022
- Pubmed Id
- 29159022
- Doi
- 10.1016/j.apsb.2017.05.006
- Paper Title
- Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1
- Paper Abstract
- As a leading cause of respiratory disease, influenza A virus (IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH) is a famous traditional Chinese medicine (TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB), which subsequently upregulated heme oxygenase-1 (HO-1) expression. Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions, CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway.
- Journal
- Acta Pharm Sin B
- Publish Year
- 2017
- Experiment Subject
- madin-darby canine kidney (mdck) cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Respiratory Disease
- Paper Title Cn
- Paper Title En
- Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1
- Bilingual Status
- semi_complete