ReferenceID 3191
Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation
Neural Regen Res
Trans-(-)-epsilon-viniferin (epsilon-viniferin) has antioxidative and anti-inflammatory effects. It also has neuroprotective effects in Huntington's disease by activating the SIRT3/LKB1/AMPK signaling pathway; however, i
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Record Fields
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- Reference Id
- 3191
- Evidence Id
- 19781
- Core Evidence Id
- 19781
- Source Reference Id
- 6359
- Herb2 Reference Id
- HBREF007156
- Subject Paper Key
- HBIN049233_32394973
- Pubmed Id
- 32394973
- Doi
- 10.4103/1673-5374.282264
- Paper Title
- Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation
- Paper Abstract
- Trans-(-)-epsilon-viniferin (epsilon-viniferin) has antioxidative and anti-inflammatory effects. It also has neuroprotective effects in Huntington's disease by activating the SIRT3/LKB1/AMPK signaling pathway; however, it remains unknown whether epsilon-viniferin also has a neuroprotective role in Parkinson's disease. A Parkinson's disease cell model was induced by exposing SH-SY5Y cells to 3.0 muM rotenone for 24 hours, and cells were then treated with 1.0 muM epsilon-viniferin for 24 hours. Treatment with epsilon-viniferin upregulated SIRT3 expression, which promoted FOXO3 deacetylation and nuclear localization. epsilon-Viniferin also increased ATP production and decreased reactive oxygen species production. Furthermore, epsilon-viniferin treatment alleviated rotenone-induced mitochondrial depolarization and reduced cell apoptosis, and restored the expression of mitochondrial homeostasis-related proteins. However, when cells were transfected with SIRT3 or FOXO3 shRNA prior to rotenone and epsilon-viniferin treatment, these changes were reversed. The results from the present study indicate that epsilon-viniferin enhances SIRT3-mediated FOXO3 deacetylation, reduces oxidative stress, and maintains mitochondrial homeostasis, thus inhibiting rotenone-induced cell apoptosis. epsilon-Viniferin may therefore be a promising treatment strategy for Parkinson's disease.
- Journal
- Neural Regen Res
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Parkinson's Disease; Huntington's Disease
- Paper Title Cn
- Paper Title En
- Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation
- Bilingual Status
- semi_complete