ReferenceID 3116
Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor
Mol Ther Oncolytics
Liver cancer is the fastest growing cause of cancer deaths in the United States due to its aggressiveness and lack of effective therapies. The current preclinical study examines valeric acid (pentanoic acid [C5H10O2]), o
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- Reference Id
- 3116
- Evidence Id
- 19706
- Core Evidence Id
- 19706
- Source Reference Id
- 6221
- Herb2 Reference Id
- HBREF007018
- Subject Paper Key
- HBIN047714_33024815
- Pubmed Id
- 33024815
- Doi
- 10.1016/j.omto.2020.08.017
- Paper Title
- Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor
- Paper Abstract
- Liver cancer is the fastest growing cause of cancer deaths in the United States due to its aggressiveness and lack of effective therapies. The current preclinical study examines valeric acid (pentanoic acid [C5H10O2]), one of the main compounds of valerian root extract, for its therapeutic use in liver cancer treatment. Anticancer efficacy of valeric acid was tested in a series of in vitro assays and orthotopic xenograft mouse models. The molecular target of valeric acid was also predicted, followed by functional confirmation. Valeric acid has a broad spectrum of anticancer activity with specifically high cytotoxicity for liver cancer in cell proliferation, colony formation, wound healing, cell invasion, and 3D spheroid formation assays. Mouse models further demonstrate that systematic administration of lipid-based nanoparticle-encapsulated valeric acid significantly reduces the tumor burden and improves survival rate. Histone deacetylase (HDAC)-inhibiting functions of valeric acid are also revealed by a structural target prediction tool and HDAC activity assay. Further transcriptional profiling and network analyses illustrate that valeric acid affects several cancer-related pathways that may induce apoptosis. In summary, we demonstrate for the first time that valeric acid suppresses liver cancer development by acting as a potential novel HDAC inhibitor, which warrants further investigation on its therapeutic implications.
- Journal
- Mol Ther Oncolytics
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Liver Cancer; Tumor; Cancer
- Paper Title Cn
- Paper Title En
- Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor
- Bilingual Status
- semi_complete