ReferenceID 3097
Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis
Eur J Immunol
Ursodeoxycholic acid (UDCA) is the primary treatment for primary biliary cholangitis (PBC), but its mechanism of action remains unclear. Studies suggest that UDCA enhances NF erythroid 2-related factor 2 (NFE2L2) express
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Record Fields
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- Reference Id
- 3097
- Evidence Id
- 19687
- Core Evidence Id
- 19687
- Source Reference Id
- 6190
- Herb2 Reference Id
- HBREF006987
- Subject Paper Key
- HBIN047610_33710617
- Pubmed Id
- 33710617
- Doi
- 10.1002/eji.202048589
- Paper Title
- Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis
- Paper Abstract
- Ursodeoxycholic acid (UDCA) is the primary treatment for primary biliary cholangitis (PBC), but its mechanism of action remains unclear. Studies suggest that UDCA enhances NF erythroid 2-related factor 2 (NFE2L2) expression and that the interaction between IFN-gamma and C-X3-C motif chemokine ligand 1 (CX3CL1) facilitates biliary inflammation in PBC. Therefore, we examined the effects of UDCA on the expression of IFN-gamma and CX3CL1 in in vitro and in vivo PBC models such as human liver tissue, a murine model, cell lines, and isolated human intrahepatic biliary epithelial cells (IHBECs). We observed a significant decrease in IFN-gamma mRNA levels and positive correlations between IFN-gamma and CX3CL1 mRNA levels post-UDCA treatment in PBC livers. NFE2L2-mediated transcriptional activation was significantly enhanced in UDCA-treated Jurkat cells. In 2-octynoic acid-immunized mice, IFN-gamma production by liver-infiltrating T cells was dependent on NFE2L2 activation. IFN-gamma significantly and dose-dependentlyinduced CX3CL1 expression, which was significantly decreased in HuCC-T1 cells and IHBECs upon UDCA treatment. These results suggest that UDCA-induced suppression of IFN-gamma and CX3CL1 production attenuates the chemotactic and adhesive abilities of liver-infiltrating T cells in PBC.
- Journal
- Eur J Immunol
- Publish Year
- 2021
- Experiment Subject
- mouse; human; cell lines; hucc-t1 cells; udca-treated jurkat cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Primary Biliary Cholangitis
- Paper Title Cn
- Paper Title En
- Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis
- Bilingual Status
- semi_complete