ReferenceID 2990
Tomatidine Suppresses the Destructive Behaviors of Fibroblast-Like Synoviocytes and Ameliorates Type II Collagen-Induced Arthritis in Rats
Front Pharmacol
Fibroblast-like synoviocytes (FLSs) are the prominent non-immune cells in synovium and play a pivotal role in rheumatoid arthritis (RA) pathogenesis. Searching for natural compounds that may suppress the pathological phe
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2990
- Evidence Id
- 19580
- Core Evidence Id
- 19580
- Source Reference Id
- 5984
- Herb2 Reference Id
- HBREF006781
- Subject Paper Key
- HBIN046526_34512321
- Pubmed Id
- 34512321
- Doi
- 10.3389/fphar.2021.670707
- Paper Title
- Tomatidine Suppresses the Destructive Behaviors of Fibroblast-Like Synoviocytes and Ameliorates Type II Collagen-Induced Arthritis in Rats
- Paper Abstract
- Fibroblast-like synoviocytes (FLSs) are the prominent non-immune cells in synovium and play a pivotal role in rheumatoid arthritis (RA) pathogenesis. Searching for natural compounds that may suppress the pathological phenotypes of FLSs is important for the development of RA treatment. Tomatidine (Td), a steroidal alkaloid derived from the solanaceae family, has been reported to have anti-inflammatory, anti-tumor and immunomodulatory effects. However, its effect on RA remains unknown. Here, we examined the inhibitory effect of Td on TNFalpha-induced arthritic FLSs, and subsequently investigated its therapeutic effect on collagen-induced arthritis (CIA) rats. Our results revealed that Td significantly inhibited TNFalpha-induced proliferation and migration of arthritic FLSs. In addition, we found that Td treatment could efficaciously ameliorate synovial inflammation and joint destruction of rats with CIA. Both in vitro and in vivo studies showed that Td significantly suppressed the production of pro-inflammatory cytokines including IL-1beta, IL-6 and TNFalpha, and downregulated the expression of MMP-9 and RANKL. Further molecular mechanism studies revealed that the inhibitory effect of Td on RA might attribute to the decreased activations of MAPKs (ERK and JNK) and NF-kappaB. These findings provide evidence that Td has the potential to be developed into a complementary or alternative agent for RA therapy.
- Journal
- Front Pharmacol
- Publish Year
- 2021
- Experiment Subject
- rat; tnfalpha-induced arthritic flss
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Rheumatoid Arthritis; Synovial Inflammation; Collagen-induced Arthritis
- Paper Title Cn
- Paper Title En
- Tomatidine Suppresses the Destructive Behaviors of Fibroblast-Like Synoviocytes and Ameliorates Type II Collagen-Induced Arthritis in Rats
- Bilingual Status
- semi_complete