ReferenceID 2926
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation
Cell Rep
Metabolic rewiring is essential for Th17 cells' functional identity to sense and interpret environmental cues. However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potentia
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Record Fields
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- Reference Id
- 2926
- Evidence Id
- 19516
- Core Evidence Id
- 19516
- Source Reference Id
- 6251
- Herb2 Reference Id
- HBREF007048
- Subject Paper Key
- HBIN048044_36450257
- Pubmed Id
- 36450257
- Doi
- 10.1016/j.celrep.2022.111741
- Paper Title
- Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation
- Paper Abstract
- Metabolic rewiring is essential for Th17 cells' functional identity to sense and interpret environmental cues. However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic opportunities to autoimmune diseases, remain largely unknown. Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) restrains Th17 cell differentiation as well as related autoimmune diseases such as experimental autoimmune encephalomyelitis and colitis. Mechanistically, VB5 is catabolized into coenzyme A (CoA) in a pantothenate kinase (PANK)-dependent manner, and in turn, CoA binds to pyruvate kinase isoform 2 (PKM2) to impede its phosphorylation and nuclear translocation, thus inhibiting glycolysis and STAT3 phosphorylation. In humans, reduced serum VB5 levels are found in both IBD and MS patients. Collectively, our study demonstrates a role of VB5 in Th17 cell metabolic reprograming, thus providing a potential therapeutic intervention for Th17 cell-associated autoimmune diseases.
- Journal
- Cell Rep
- Publish Year
- 2022
- Experiment Subject
- human; patient
- Experiment Type
- Cell Experiment
- Phenotype Related
- Experimental Autoimmune Encephalomyelitis; Th17 Cell-associated Autoimmune Diseases; Autoimmune Diseases; Colitis
- Paper Title Cn
- Paper Title En
- Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation
- Bilingual Status
- semi_complete