ReferenceID 2882
Systemic and topical administration of spermidine accelerates skin wound healing
Cell Commun Signal
BACKGROUND: The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type p
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- Reference Id
- 2882
- Evidence Id
- 19472
- Core Evidence Id
- 19472
- Source Reference Id
- 5748
- Herb2 Reference Id
- HBREF006545
- Subject Paper Key
- HBIN044493_33752688
- Pubmed Id
- 33752688
- Doi
- 10.1186/s12964-021-00717-y
- Paper Title
- Systemic and topical administration of spermidine accelerates skin wound healing
- Paper Abstract
- BACKGROUND: The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) signaling in vitro. Here, we investigated whether the systemic and topical administration of SPD would accelerate the skin wound-repair process in vivo. METHODS: A skin wound repair model was established using C57BL/6 J mice. SPD was mixed with white petrolatum for topical administration. For systemic administration, SPD mixed with drinking water was orally administered. Changes in wound size over time were calculated using digital photography. RESULTS: Systemic and topical SPD treatment significantly accelerated skin wound healing. The administration of SPD promoted the uPA/uPAR pathway in wound sites. Moreover, topical treatment with SPD enhanced the expression of IL-6 and TNF-alpha in wound sites. Scratch and cell proliferation assays revealed that SPD administration accelerated scratch wound closure and cell proliferation in vitro. CONCLUSION: These results indicate that treatment with SPD promotes skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response in wound sites. The administration of SPD might contribute to new effective treatments to accelerate skin wound healing. Video Abstract.
- Journal
- Cell Commun Signal
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Systemic and topical administration of spermidine accelerates skin wound healing
- Bilingual Status
- semi_complete