ReferenceID 2860
Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
World J Gastroenterol
BACKGROUND: Sinapic acid (SA) has been shown to have various pharmacological properties such as antioxidant, antifibrotic, anti-inflammatory, and anticancer activities. Its mechanism of action is dependent upon its abili
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- Reference Id
- 2860
- Evidence Id
- 19450
- Core Evidence Id
- 19450
- Source Reference Id
- 5709
- Herb2 Reference Id
- HBREF006506
- Subject Paper Key
- HBIN044062_33642831
- Pubmed Id
- 33642831
- Doi
- 10.3748/wjg.v27.i7.592
- Paper Title
- Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
- Paper Abstract
- BACKGROUND: Sinapic acid (SA) has been shown to have various pharmacological properties such as antioxidant, antifibrotic, anti-inflammatory, and anticancer activities. Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries. AIM: To study the hepatoprotective effects of SA against lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute liver failure (ALF) in rats. METHODS: Experimental ALF was induced with an intraperitoneal (i.p.) administration of 8 mug LPS and 800 mg/kg D-GalN in normal saline. SA was administered orally once daily starting 7 d before LPS/D-GalN treatment. RESULTS: Data showed that SA ameliorates acute liver dysfunction, decreases serum levels of alanine transaminase (ALT), and aspartate aminotransferase (AST), as well as malondialdehyde (MDA) and NO levels in ALF model rats. However, pretreatment with SA (20 mg/kg and 40 mg/kg) reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation and levels of inflammatory cytokines (tumor necrosis factor-alpha and interleukin 6). Also, SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway. CONCLUSION: In conclusion, SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-kappaB.
- Journal
- World J Gastroenterol
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Cell Experiment
- Phenotype Related
- Tumor; Acute Liver Dysfunction; Acute Liver Failure
- Paper Title Cn
- Paper Title En
- Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
- Bilingual Status
- semi_complete