ReferenceID 2846
Promotive effects of sesamin on proliferation and adhesion of intestinal probiotics and its mechanism of action
Food Chem Toxicol
The effect of sesamin on intestinal flora was studied by in vitro animal fecal anaerobic fermentation system, and were analyzed by 16S rDNA sequencing. Results showed that sesamin modulated the composition of intestinal
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Record Fields
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- Reference Id
- 2846
- Evidence Id
- 19436
- Core Evidence Id
- 19436
- Source Reference Id
- 5681
- Herb2 Reference Id
- HBREF006478
- Subject Paper Key
- HBIN043798_33561518
- Pubmed Id
- 33561518
- Doi
- 10.1016/j.fct.2021.112049
- Paper Title
- Promotive effects of sesamin on proliferation and adhesion of intestinal probiotics and its mechanism of action
- Paper Abstract
- The effect of sesamin on intestinal flora was studied by in vitro animal fecal anaerobic fermentation system, and were analyzed by 16S rDNA sequencing. Results showed that sesamin modulated the composition of intestinal microorganisms and reshaped gut microbiome. The abundance of probiotics Lactobacillaceae and Bifidobacteriaceae increased, while the abundance of Enterobacteriaceae decreased. The properties of probiotics (Bifidobacterium bifidum and Lactophilus acidophilus) adhesion to epithelial colon cells (NCM460) were assessed by gram staining and plate counting methods. Results showed that sesamin increased the adhesive index of probiotics. Analysis of RT-qPCR, Western blot and immunofluorescence staining indicated that sesamin up-regulated the expression of the adhesive protein (beta-cadherin and E-cadherin) of NCM460 cells. In conclusion, sesamin could promote the proliferation and adhesion of intestinal probiotics leading to modulating gut microbiota, which provided basis for sesamin as a food-borne functional factor for improving intestinal health.
- Journal
- Food Chem Toxicol
- Publish Year
- 2021
- Experiment Subject
- ncm460 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Promotive effects of sesamin on proliferation and adhesion of intestinal probiotics and its mechanism of action
- Bilingual Status
- semi_complete